rasH2 Related Publications

Gulezian D, Jacobson-Kram D, McCullough CB, Olson H, Recio L, Robinson D, Storer R, Tennant R, Ward JM, Neumann DA. (2000) Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment. Toxicol Pathol. 28(3):482-99.

Kanno H, Tanakamaru ZY, Ishimura Y, Kandori H, Yamasaki H, Sasaki S. (2003) Historical Background Data in CB6F1-Tg-rasH2 Mice and CB6F1-nonTg-rasH2 Mice over a 26-Week Experimental Period. J Toxicol Pathol. 16(4):267-274.

Maronpot RR, Mitsumori K, Mann P, Takaoka M, Yamamoto S, Usui T, Okamiya H, Nishikawa S, Nomura T. (2000) Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model. Toxicology. 146(2-3):149-59.

Mitsumori K, Koizumi H, Nomura T, Yamamoto S. (1998) Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies. Toxicol Pathol. 26(4):520-31.

Morton D, Alden CL, Roth AJ, Usui T. (2002) The Tg rasH2 mouse in cancer hazard identification. Toxicol Pathol. 30(1):139-46.

Ohnishi Y, Arai T, Koshirakawa M, Horii N, Nakajo S, Urano K, Usui T, Tamaoki N, Ueyama Y. (2001) Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates. Exp Anim. 50(1):33-9.

Suemizu H, Muguruma K, Maruyama C, Tomisawa M, Kimura M, Hioki K, Shimozawa N, Ohnishi Y, Tamaoki N, Nomura T. (2002) Transgene stability and features of rasH2 mice as an animal model for short-term carcinogenicity testing. Mol Carcinog. 34(1):1-9.

Takegawa K, Mitsumori K, Yasuhara K, Moriyasu M, Sakamori M, Onodera H, Hirose M, Nomura T. (2000) A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice. Toxicol Pathol. 28(5):649-55.

Urano K, Suzuki S, Machida K, Sawa N, Eguchi N, Kikuchi K, Fukasawa K, Taguchi F, Usui T. (2006) Use of IC tags in short-term carcinogenicity study on CB6F1 TGrasH2 mice. J Toxicol Sci. 31(5):407-18.

Usui T, Mutai M, Hisada S, Takoaka M, Soper KA, McCullough B, Alden C. (2001) CB6F1-rasH2 mouse: overview of available data. Toxicol Pathol. 29 Suppl:90-108.

Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M, Nomura G, Hioki K, Wakana S, Nomura T, Hayashi Y. (1996) Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis. 17(11):2455-61.

Yamamoto S, Urano K, Nomura T. (1998) Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Toxicol Lett. 102-103:473-8.