PXR Related Publications

Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL. (2006) Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor α, and the Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator-1α. J Biol Chem. 281(36):26540-51.

Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ. (2003) Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity. J Biol Chem. 278(46):45062-71.

Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, Gonzalez FJ. (2004) Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor. Toxicol Sci. 82(2):372-80.

Kliewer SA, Willson TM. (2002) Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res. 43(3):359-64.

Nakamura K, Moore R, Negishi M, Sueyoshi T. (2007) Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver. J Biol Chem. 282(13):9768-76.

Shah YM, Ma X, Morimura K, Kim I, Gonzalez FJ. (2007) Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression. Am J Physiol Gastrointest Liver Physiol. 292(4):G1114-22.

Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA. 98(6):3369-74.

Staudinger JL, Liu Y, Madan A, Habeebu S, Klaassen CD. (2001) Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor. Drug Metab Dispos. 29(11):1467-72.

Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. (2006) Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity. J Biol Chem. 281(24):16625-31.