Goto-Kakizaki Related Publications

Barbu A, Hedlund GP, Lind J, Carlsson C. (2009) Pref-1 and adipokine expression in adipose tissues of GK and Zucker rats. Mol Cell Endocrinol. 299(2):163-71.

Beddow SA, Samuel VT. (2012) Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes. Dis Model Mech. 5(5):681-5.

Begum N, Ragolia L. (1998) Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats. Metabolism. 47(1):54-62.

Bitar MS, Al-Saleh E, Al-Mulla F. (2005) Oxidative stress-mediated alterations in glucose dynamics in a genetic animal model of type II diabetes. Life Sci. 77(20):2552-73.

Cao Y, DuBois DC, Almon RR, Jusko WJ. (2012) Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats. Biopharm Drug Dispos. 33(6):285-91.

Cao Y, Dubois DC, Sun H, Almon RR, Jusko WJ. (2011) Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats. J Pharmacol Exp Ther. 339(3):896-904.

Desrois M, Sidell RJ, Gauguier D, Davey CL, Radda GK, Clarke K. (2004) Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart. J Mol Cell Cardiol. 37(2):547-55.

Esguerra JL, Bolmeson C, Cilio CM, Eliasson L. (2011) Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat. PLoS One. 6(4):e18613.

Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A. (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet. 12(1):38-43.

Goto Y, Kakizaki M, Masaki N. (1976) Production of spontaneous diabetic rats by repetition of selective breeding. Tohoku J Exp Med. 119(1):85-90.

Goto Y, Suzuki K, Ono T, Sasaki M, Toyota T. (1988) Development of diabetes in the non-obese NIDDM rat (GK rat). Adv Exp Med Biol. 246:29-31.

Guan W, Kozak A, Fagan SC. (2011) Drug repurposing for vascular protection after acute ischemic stroke. Acta Neurochir Suppl. 111:295-8.

Grönholm T, Cheng ZJ, Palojoki E, Eriksson A, Bäcklund T, Vuolteenaho O, Finckenberg P, Laine M, Mervaala E, Tikkanen I. (2005) Vasopeptidase inhibition has beneficial cardiac effects in spontaneously diabetic Goto-Kakizaki rats. Eur J Pharmacol. 519(3):267-76.

Gupte S, Labinskyy N, Gupte R, Csiszar A, Ungvari Z, Edwards JG. (2010) Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM. PLoS One. 5(7):e11800.

Harris AK, Hutchinson JR, Sachidanandam K, Johnson MH, Dorrance AM, Stepp DW, Fagan SC, Ergul A. (2005) Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1. Diabetes. 54(9):2638-44.

Janssen U, Phillips AO, Floege J. (1999) Rodent models of nephropathy associated with type II diabetes. J Nephrol. 12(3):159-72.

Jørgensen W1, Jelnes P, Rud KA, Hansen LL, Grunnet N, Quistorff B. (2012) Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only. Am J Physiol Endocrinol Metab. 303(4):E515-23.

King AJ. (2012) The use of animal models in diabetes research. British Journal of Pharmacolog. 166: 877-894.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F. (2009) Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat. PLoS One. 4(9):e6963.

Lærke HN, Meyer AS, Kaack KV, Larsen T. (2007) Soluble fiber extracted from potato pulp is highly fermentable but has no effect on risk markers of diabetes and cardiovascular disease in Goto-Kakizaki rats. Nutrition Research. 27(3):152-160.

Landersdorfer CB, DuBois DC, Almon RR, Jusko WJ. (2009) Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats. J Pharmacol Exp Ther. 328(2):644-51.

Miyamoto K, Ogura Y, Nishiwaki H, Matsuda N, Honda Y, Kato S, Ishida H, Seino Y. (1996) Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes. Invest Ophthalmol Vis Sci. 37(5):898-905.

Movassat J, Saulnier C, Serradas P, Portha B. (1997) Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia. 40(8):916-25.

Nie J. (2010) Muscle biomarkers of type 2 diabetes disease progression in Goto-Kakizaki rats. A dissertation submitted to the Faculty of the Graduate School of the State University of New York at Buffalo, 2010, 293 pages. Dissertation.

Nie J, Xue B, Sukumaran S, Jusko WJ, Dubois DC, Almon RR. (2011) Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats. Mol Cell Endocrinol. 338(1-2):10-7.

Nobrega MA, Solberg Woods LC, Fleming S, Jacob HJ. (2009) Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat. Physiol Genomics. 39(1):38-46.

Omri S, Behar-Cohen F, de Kozak Y, Sennlaub F, Verissimo LM, Jonet L, Savoldelli M, Omri B, Crisanti P. (2011) Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKCζ in the Goto Kakizaki rat model. Am J Pathol. 179(2):942-53.

Omri S, Omri B, Savoldelli M, Jonet L, Thillaye-Goldenberg B, Thuret G, Gain P, Jeanny JC, Crisanti P, Behar-Cohen F. (2010) The outer limiting membrane (OLM) revisited: clinical implications. Clin Ophthalmol. 4:183-95.

Portha B, Lacraz G, Chavey A, Figeac F, Fradet M, Tourrel-Cuzin C, Homo-Delarche F, Giroix MH, Bailbé D, Gangnerau MN, Movassat J. (2010) Islet structure and function in the GK rat. Adv Exp Med Biol. 654:479-500.

Portha B, Lacraz G, Kergoat M, Homo-Delarche F, Giroix MH, Bailbé D, Gangnerau MN, Dolz M, Tourrel-Cuzin C, Movassat J. (2009) The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes? Mol Cell Endocrinol. 297(1-2):73-85.

Portha B. (2005) Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm. Diabetes Metab Res Rev. 21(6):495-504.

Ragolia L, Palaia T, Koutrouby TB, Maesaka JK. (2004) Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats. Am J Physiol Cell Physiol. 287(5):C1273-81.

Serradas P, Goya L, Lacorne M, Gangnerau MN, Ramos S, Alvarez C, Pascual-Leone AM, Portha B. (2002) Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes. Diabetes. 51(2):392-7.

Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, Placido J, Zito SW. (2008) Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats. Carbohydr Res. 343(7):1278-81.

Schrijvers BF, De Vriese AS, Van de Voorde J, Rasch R, Lameire NH, Flyvbjerg A. (2004) Long-term renal changes in the Goto-Kakizaki rat, a model of lean type 2 diabetes. Nephrol Dial Transplant. 19(5):1092-7.

Speck M, Cho YM, Asadi A, Rubino F, Kieffer TJ. (2011) Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab. 300(5):E923-32.