CRT Repository Related Publications

Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH. (2009) The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell. 137(6):1124-35.

Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. (2009) Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 17(2):175-86.

Mahmoud M, Allinson KR, Zhai Z, Oakenfull R, Ghandi P, Adams RH, Fruttiger M, Arthur HM. (2010) Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res. 106(8):1425-33.

Robson A, Allinson KR, Anderson RH, Henderson DJ, Arthur HM. (2010) The TGFβ type II receptor plays a critical role in the endothelial cells during cardiac development. Dev Dyn. 239(9):2435-42.

Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH. (2010) Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 465(7297):483-6.

Luna-Zurita L1, Prados B, Grego-Bessa J, Luxán G, del Monte G, Benguría A, Adams RH, Pérez-Pomares JM, de la Pompa JL. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 120(10):3493-507.

Dellavalle A, Maroli G, Covarello D, Azzoni E, Innocenzi A, Perani L, Antonini S, Sambasivan R, Brunelli S, Tajbakhsh S, Cossu G. (2011) Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nat Commun. 2:499.

Hoch M, Fischer P, Stapel B, Missol-Kolka E, Sekkali B, Scherr M, Favret F, Braun T, Eder M, Schuster-Gossler K, Gossler A, Hilfiker A, Balligand JL, Drexler H, Hilfiker-Kleiner D. (2011) Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell. 9(2):131-43.

Bréart B, Ramos-Perez WD, Mendoza A, Salous AK, Gobert M, Huang Y, Adams RH, Lafaille JJ, Escalante-Alcalde D, Morris AJ, Schwab SR. (2011) Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med. 208(6):1267-78.

Boulday G, Rudini N, Maddaluno L, Blécon A, Arnould M, Gaudric A, Chapon F, Adams RH, Dejana E, Tournier-Lasserve E. (2011) Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med. 208(9):1835-47.

Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY, Rafii S. (2011) Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 147(3):539-53.

Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL. (2012) Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 14(10):1046-56.

Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams RH. (2012) Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS One. 7(7):e41116.

Trindade A, Djokovic D, Gigante J, Badenes M, Pedrosa AR, Fernandes AC, Lopes-da-Costa L, Krasnoperov V, Liu R, Gill PS, Duarte A. (2012) Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis. PLoS One. 7(1):e29863.

Allinson KR, Lee HS, Fruttiger M, McCarty JH, Arthur HM. (2012) Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system. PLoS One. 7(6):e39336.

Sabine A1, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hägerling R, Pollmann C, Bebber D, Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Mäkinen T, Kiefer F, Kwak BR, Petrova TV. (2012) Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. Dev Cell. 22(2):430-45.

Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH. (2012) Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature. 484(7392):110-4.

Naito H, Kidoya H, Sakimoto S, Wakabayashi T, Takakura N. (2012) Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels. EMBO J. 31(4):842-55.

Gaengel K, Niaudet C, Hagikura K, Laviña B, Muhl L, Hofmann JJ, Ebarasi L, Nyström S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellström M, Fuxe J, Uhlén P, Adams R, Jakobsson L, Majumdar A, Vestweber D, Uv A, Betsholtz C. (2012) The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell. 23(3):587-99.

Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T. (2012) Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. 23(3):600-10.

Fantin A, Vieira JM, Plein A, Denti L, Fruttiger M, Pollard JW, Ruhrberg C. (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood. 121(12):2352-62.

Yang H, Lee S, Lee S, Kim K, Yang Y, Kim JH, Adams RH, Wells JM, Morrison SJ, Koh GY, Kim I. (2013) Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest. 123(1):418-31.

Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol. 15(3):249-60.

Luxán G, Casanova JC, Martínez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL. (2013) Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med. 19(2):193-201.

Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH. (2013) Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J. 32(2):219-30.
Brooker R, Hozumi K, Lewis J. (2006) Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 133(7):1277-86.

Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM. (2008) Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol. 128(4):825-32.

Feller J, Schneider A, Schuster-Gossler K, Gossler A. (2008) Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev. 22(16):2166-71.

Kawaguchi D, Yoshimatsu T, Hozumi K, Gotoh Y. (2008) Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon. Development. 135(23):3849-58.

Kwon SM, Eguchi M, Wada M, Iwami Y, Hozumi K, Iwaguro H, Masuda H, Kawamoto A, Asahara T. (2008) Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization. Circulation. 118(2):157-65.

Rocha SF, Lopes SS, Gossler A, Henrique D. (2009) Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev Biol. 328(1):54-65.

Sörensen I, Adams RH, Gossler A. (2009) DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 113(22):5680-8.

Stamataki D, Holder M, Hodgetts C, Jeffery R, Nye E, Spencer-Dene B, Winton DJ, Lewis J. (2011) Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One. 6(9):e24484.

Grainger S, Lam J, Savory JG, Mears AJ, Rijli FM, Lohnes D. (2012) Cdx regulates Dll1 in multiple lineages. Dev Biol. 361(1):1-11.
Ye X, Wang Y, Cahill H, Yu M, Badea TC, Smallwood PM, Peachey NS, Nathans J. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 139(2):285-98.
Yang YG, Lindahl T, Barnes DE. (2007) Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell. 131(5):873-86.

Stetson DB, Ko JS, Heidmann T, Medzhitov R. (2008) Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 134(4):587-98.

Beck-Engeser GB1, Eilat D, Harrer T, Jäck HM, Wabl M. (2009) Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. Proc Natl Acad Sci USA. 106(49):20865-70.

Lindahl T, Barnes DE, Yang YG, Robins P. (2009) Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem Soc Trans. 37(Pt3):535-8.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB. (2012) Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 36(1):120-31.

Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N. (2013) Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol. 14(1):61-71.