CIEA BRG mouse Related Publications

Immunity - Hematopoietic stem cell engraftment

Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF. (2006) Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc Natl Acad Sci USA. 103(43):15951-6.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R. (2006) HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology. 3:76.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R. (2008) Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice. Virology. 373(2):342-51.

Chicha L, Tussiwand R, Traggiai E, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. (2005) Human adaptive immune system Rag2-/-gamma(c)-/- mice. Ann N Y Acad Sci. 1044:236-43.

Choudhary SK, Rezk NL, Ince WL, Cheema M, Zhang L, Su L, Swanstrom R, Kashuba AD, Margolis DM. (2009) Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. J Virol. 83(16):8254-8.

Frecha C, Costa C, Négre D, Amirache F, Trono D, Rio P, Bueren J, Cosset FL, Verhoeyen E. (2012) A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. Blood. 119(5):1139-50.

Frecha C, Toscano MG, Costa C, Saez-Lara MJ, Cosset FL, Verhoeyen E, Martin F. (2008) Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Ther. 15(12):930-41.

Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L. (2007) Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J Virol. 81(6):2700-12.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF. (2008) RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J Virol. 82(24):12145-53.

Kwant-Mitchell A, Ashkar AA, Rosenthal KL. (2009) Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. J Virol. 83(20):10664-76.

Kwant-Mitchell A, Pek EA, Rosenthal KL, Ashkar AA. (2009) Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS One. 4(12):e8379.

Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. (2011) Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2rγnull mouse model: a multivariable optimization approach. Clin Immunol. 140(1):102-16.

Pek EA, Chan T, Reid S, Ashkar AA. (2011) Characterization and IL-15 dependence of NK cells in humanized mice. Immunobiology. 216(1-2):218-24.

Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. (2004) Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 304(5667):104-7.

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Immunity - Immune signaling

Barra NG, Chew MV, Reid S, Ashkar AA. (2012) Interleukin-15 treatment induces weight loss independent of lymphocytes. PLoS One. 7(6):e39553.

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Gene Therapy

Frecha C, Costa C, Nègre D, Amirache F, Trono D, Rio P, Bueren J, Cosset FL, Verhoeyen E. (2012) A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. Blood. 119(5):1139-50.

Frecha C, Toscano MG, Costa C, Saez-Lara MJ, Cosset FL, Verhoeyen E, Martin F. (2008) Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Ther. 15(12):930-41 .

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Autoimmune Disease

Andrade D, Redecha PB, Vukelic M, Qing X, Perino G, Salmon JE, Koo GC. (2011) Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2-/- IL-2Rγ-/- mice: a promising model for studying human disease. Arthritis Rheum. 63(9):2764-73.

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Graft versus Host Disease

Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M. (2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation. 87(11):1654-8.

Noguchi D, Wakita D, Ohkuri T, Tajima M, Chamoto K, Kitamura H, Nishimura T. (2011) Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen. Immunol Lett. 136(2):146-55.

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Cancer

Bertilaccio MT, Scielzo C, Simonetti G, Ponzoni M, Apollonio B, Fazi C, Scarfò L, Rocchi M, Muzio M, Caligaris-Cappio F, Ghia P. (2010)A novel Rag2-/-gammac-/--xenograft model of human CLL. Blood. 115(8):1605-9.

De Giovanni C, Nicoletti G, Landuzzi L, Romani F, Croci S, Palladini A, Murgo A, Antognoli A, Ianzano ML, Stivani V, Grosso V, Iezzi M, Stramucci L, Barbieri E, Lemoli RM, Nanni P, Lollini PL. (2012) Human responses against HER-2-positive cancer cells in human immune system-engrafted mice. Br J Cancer. 107(8):1302-9.

Klar R, Schober S, Rami M, Mall S, Merl J, Hauck SM, Ueffing M, Admon A, Slotta-Huspenina J, Schwaiger M, Stevanović S, Oostendorp RA, Busch DH, Peschel C, Krackhardt AM. (2014) Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells. Leukemia. 28(12):2355-66.

Kwant-Mitchell A, Pek EA, Rosenthal KL, Ashkar AA. (2009) Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS One. 4(12):e8379.

Lollini PL, De Giovanni C, Nanni P. (2013) Preclinical HER-2 Vaccines: From Rodent to Human HER-2. Front Oncol. 3:151.

Nanni P, Nicoletti G, Palladini A, Croci S, Murgo A, Ianzano ML, Grosso V, Stivani V, Antognoli A, Lamolinara A, Landuzzi L, di Tomaso E, Iezzi M, De Giovanni C, Lollini PL. (2012) Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor. PLoS One. 7(6):e39626.

Nanni P, Nicoletti G, Landuzzi L, Croci S, Murgo A, Palladini A, Antognoli A, Ianzano ML, Stivani V, Grosso V, Maira SM, García-Echeverría C, Scotlandi K, De Giovanni C, Lollini PL. (2010) High metastatic efficiency of human sarcoma cells in Rag2/gammac double knockout mice provides a powerful test system for antimetastatic targeted therapy. Eur J Cancer. 46(3):659-68.

Scielzo C, Bertilaccio MT, Simonetti G, Dagklis A, ten Hacken E, Fazi C, Muzio M, Caiolfa V, Kitamura D, Restuccia U, Bachi A, Rocchi M, Ponzoni M, Ghia P, Caligaris-Cappio F. (2010) HS1 has a central role in the trafficking and homing of leukemic B cells. Blood. 116(18):3537-46.

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Cancer Immunotherapy

Ahmed M, Cheng M, Cheung IY, Cheung NK. (2015) Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody. Oncoimmunology. 4(4):e989776.

Cheng M, Ahmed M, Xu H, Cheung NK. (2015) Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy. Int J Cancer. 136(2):476-86.

Zhao Q, Ahmed M, Tassev DV, Hasan A, Kuo TY, Guo HF, O'Reilly RJ, Cheung NK. (2015) Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential. Leukemia. 29(11):2238-47.

Zhao Q, Ahmed M, Guo HF, Cheung IY, Cheung NK. (2015) Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8. J Biol Chem. 290(21):13017-27.

Xu H, Cheng M, Guo H, Chen Y, Huse M, Cheung NK. (2015) Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody. Cancer Immunol Res. 3(3):266-77.

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Infectious Disease

Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF. (2006) Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc Natl Acad Sci USA. 103(43):15951-6.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R. (2006) HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology. 3:76.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R. (2008) Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice. Virology. 373(2):342-51.

Choudhary SK, Rezk NL, Ince WL, Cheema M, Zhang L, Su L, Swanstrom R, Kashuba AD, Margolis DM. (2009) Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. J Virol. 83(16):8254-8.

Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L. (2007) Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J Virol. 81(6):2700-12.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF. (2008) RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J Virol. 82(24):12145-53.

Kwant-Mitchell A, Ashkar AA, Rosenthal KL. (2009) Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. J Virol. 83(20):10664-76.

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