APPSWE - Model 1349 Related Publications

Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK, Suh YH. (2006) Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol. 26(11):4327-38.

Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsaio KK. (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci. 2(3):271-6.

Dong H, Csernansky CA, Martin MV, Bertchume A, Vallera D, Csernansky JG. (2005) Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 181(1):145-52.

Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. (2003) NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 112(3):440-9.

Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsaio K, Cole GM. (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 152(1):307-17.

Kelly BL, Vassar R, Ferreira A. (2005) Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J Biol Chem. 280(36):31746-53.

Lee JY, Cole TB, Palmiter RD, Suh SW, Koh JY. (2002) Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc Natl Acad Sci USA. 99(11):7705-10.

Li Q, Cao C, Chackerian B, Schiller J, Gordon M, Ugen KE, Morgan D. (2004) Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. BMC Neurosci. 5:21.

Loeffler DA. (2004) Using animal models to determine the significance of complement activation in Alzheimer‘s disease. J Neuroinflammation. 1(1):18.

McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, DeLucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T. (2005) Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47(2):191-9.

Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Ashe KH, Carlson GA, Iadecola C. (2000) Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci USA. 97(17):9735-40.

Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD. (2005) Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer‘s models. J Neurosci. 25(18):4649-58.

Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K. (2001) Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer‘s disease. Neurobiol Dis. 8(4):555-67.

Puglielli L, Friedlich AL, Setchell KDR, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. (2005) Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest. 115(9):2556-63.

Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VMY. (2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer‘s disease. Proc Natl Acad Sci USA. 97(13):7609-14.

Spires TL, Hyman BT. (2005) Transgenic models of Alzheimer‘s disease: learning from animals. NeuroRx. 2(3):423-37.

Stobart MJ, Parchaliuk D, Simon SLR, Lemaistre J, Lazar J, Rubenstein R, Knox JD. (2007) Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease. Mol Neurodegener. 2:5.

Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT. (2002) Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer‘s disease. Proc Natl Acad Sci USA. 99(22):13990-5.

Yao Y, Chinnici C, Tang H, Trojanowski JQ, Lee VMY, Praticò D. (2004) Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. J Neuroinflammation. 1(1):21.