SOD1 Rat

Random Transgenic

SOD1 Random Transgenic Rat Model

NTac:SD Background

  • Model #
  • Genotype
  • Nomenclature
  • 2148-F
    tg/wt
    NTac:SD-Tg(SOD1G93A)L26H
  • 2148-M
    tg/wt
    NTac:SD-Tg(SOD1G93A)L26H
  • 2148-F
    wt/wt
    NTac:SD-Tg(SOD1G93A)L26H
  • 2148-M
    wt/wt
    NTac:SD-Tg(SOD1G93A)L26H
Hemizygous rats express SOD1G93A in the spinal cord ~8-fold above endogenous SOD1. SOD1G93A is also expressed across many brain regions as well as peripheral tissues. By end stage, mutant SOD1 levels accumulate ~16 fold over endogenous, representing a further 2-fold increase in SOD1G93A compared with levels in young, presymptomatic rats (6 weeks old). SOD1 rats have an average onset of motor neuron disease of 115 days, typically appearing as hind limb abnormal gait and progressing very quickly (1-2 days) to overt hind limb paralysis, typically affecting one limb first. Hemizygous rats typically reach end-stage disease an average of 11 days after onset of symptoms. The rapid decline of the SOD1G93A rats coincides with substantial loss of spinal cord motor neurons as well as marked increases in gliosis and degeneration of muscle integrity and function.

Note: Phenotypic changes have been observed in the SOD1 colony which affect disease onset. Please see the SOD1 communication for further details.

Genetic Background:

NTac:SD Background

Origin:

Created by John Kulik at Wyeth. Transgenic Model of SOD1 mediated Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease). Came to Taconic in April 2002 for David Howland at Wyeth for distribution as an Emerging Model. Joint collaboration between Wyeth and The ALS Association.



Color:

Albino

Species:

Rat

Initial Publication:

Howland et. al. Focal Loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). 1604-1609, PNAS - Feb. 5, 2002, Vol. 99, #3.



SOD1 Breeder Phenotype Data - Tracking Disease Onset at Taconic.

SOD1 Study Data - Tracking Disease Onset. Provided by: Dr. Karl A. Kasischke, Cornell University, Ithaca, NY.

SOD1 Study Data - Genotyping. Provided by: Dr. Karl A. Kasischke, Cornell University, Ithaca, NY.