NIH nude

Spontaneous Mutant

NIH nude Spontaneous Mutant Rat Model

  • Model #
  • Genotype
  • Nomenclature
  • NIHRNU-F
    sp/sp
    NTac:NIH-Foxn1rnu
  • NIHRNU-M
    sp/sp
    NTac:NIH-Foxn1rnu
  • NIHRNU-F
    sp/wt
    NTac:NIH-Foxn1rnu
  • NIHRNU-M
    sp/wt
    NTac:NIH-Foxn1rnu
  • Exhibits deficient T cell activity with lymph nodes and Peyers patches showing lymphocyte depletion in T-lymphocyte dependent regions
  • In this outbred immunodeficient model the vibrissae are present in the homozygous nude rat but bent with some short hairs on the head and occasionally on the rest of the body
  • At later ages some hair growth occurs but rats become hairless again within a few weeks
  • Skin of homozygous rat is generally pigmented, but occasionally an albino rat is seen
  • Consistent with ILAR nomenclature rules, Taconic has recently updated the nomenclature for the NIHRNU from NTac:NIH-Whn to NTac:NIH-Foxn1rnu.

Origin:

The NIH nude Spontaneous mutant model was developed by NIH in 1979-1980 by intercrossing eight strains of rats. Taconic received stock from NIH Animal Genetic Resource in 1981. The rats were derived by hysterectomy in 1987 and again in 1998. Animals are randomly bred at Taconic without selection for coat color or pigmentation.


Color:

Various

Species:

Rat



Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
Average litter size: 8