Goto-Kakizaki

Inbred

Goto Kakizaki Inbred Rat Model

  • Model #
  • Genotype
  • Nomenclature
  • GK-F
    GK/MolTac
  • GK-M
    GK/MolTac
  • A non-obese model of Non-Insulin Dependent Diabetes Mellitus (NIDDM), type II diabetes.
  • It exhibits similar metabolic, hormonal, and vascular disorders to the human diabetes disease.
  • Males develop type II diabetes at approximately 14 - 16 weeks of age.
  • Characteristics include fasting hyperglycemia, impaired secretion of insulin in response to glucose both in vivo and in isolated pancreatic cells, hepatic and peripheral insulin resistance and polyuria
  • Late complications such as retinopathy, microangiopathy, neuropathy, and nephropathy have been described in literature
  • Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.
  • The GK colony was derived from inbred stock and is bred randomly in a closed colony.

Origin:

The Goto-Kakizaki inbred model was developed by Tohoku University in 1975. Aarhus University Hospital in Denmark received stock in 1994. M&B A/S (now Taconic Europe) received stock from Aarhus in 1997. The rats were derived by embryo transfer in 2005 at Taconic US.


Genetics:

  • Strain Pro?le: Aco1b, Alpa, Amy2a, Anpepa, Es1a, Es2a, Es3a, Es4a, Es4b, Es6a, Es7b, Es9a, Esda, Es14b, Es15a, Es18a, Fh1b, Hao1a, Hbba, Pepcb , Pgd1b, Svp1a
  • Immunology: RT1-A1, RT2a

 


Coat Color Loci:

a, Tyrc

Color:

Albino

Species:

Rat


For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can routinely accept orders by weight for this model for males only. Please inquire for female options if weight is critical for your experiment. A minimum 10 gram span is required. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

n= 100 per sex at MPF health standard from US production colonies. Data collected 2012-14.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
Average litter size: 6
  • Sexual Maturity: females at approximately 8 - 10 weeks of age males at approximately 10 - 12 weeks of age
  • Pregnancy: approximately 21 - 23 days
  • Weaning: approximately 28 days of age
  • Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.