Human Alpha Synuclein Rat

Random Transgenic

Human Alpha Synuclein Random Transgenic Rat Model
This line is cryopreserved and requires cryorecovery.

NTac:SD Background

  • Model #
  • Genotype
  • Nomenclature
  • 10680-F
    tg/wt
    Tac:SD-Tg(SNCA*WT)446CJLi
  • 10680-M
    tg/wt
    Tac:SD-Tg(SNCA*WT)446CJLi
  • Line 10680 Rat carries the wild type human gene SNCA. Hemizygotes are positive for the wild type human gene SNCA.

Genetic Background:

NTac:SD Background

Origin:

Line 10680 was developed in the laboratory of Chenjian Li at Cornell. The model was created through pronuclear injection of wild type human gene SNCA into NTac:SD zygotes. Founder line 446 was bred to NTac:SD. The colony is maintained by mating a wild type female with a hemizygous male to produce hemizygous pups. Taconic received stock from Cornell in 2010 and derived the rats through embryo transfer derivation.


Source:

Model Sponsor: The Michael J. Fox Foundation

Color:

Albino

Species:

Rat

Initial Publication:

Initial characterization of this model is in progress.



Terms of Use:
Rats may be cryo-recovered at Taconic. Nonprofit users may access rats for research purposes under a simple label license (no signatures required). For-profit users must first execute a license agreement with Cornell University.

Conditions of Use for Parkinson's Disease Rat Models for Nonprofit Users:
The Parkinson's Disease Rat Models (Model), Taconic Models 10678, 10679, 10680, and 10681, are produced and distributed under rights to patents and/or intellectual property owned by Cornell University (Cornell). Taconic has rights to distribute the Model on behalf of Cornell. Cornell maintains ownership of the Model and permits the sale of such rats to each Buyer that agrees to the following Terms and Conditions of the Sale and following terms of use:

  • Title to the Model and biological materials derived from it remains with Cornell.
  • The Model will be used for research purposes only.
  • The Model may be bred, but may not be crossbred to another transgenic line or backcrossed to another strain background without the written consent of Cornell.
  • In publications of results with the Model, Recipient must cite Chenjian Li of Weill Cornell Medical College as creator of the Model.
  • The Model and biological materials derived from it will not be distributed to third parties (except to send tissues to a nonprofit collaborator or for fee-for-service staining or analysis work).
  • The Model and biological materials derived from it will not be used for commercial purposes.
  • Recipient may not use Model in research funded by a for-profit entity unless said for-profit has obtained a license for the Model from Cornell.
  • Recipient assumes all risk from using the Model and holds Cornell and its employees harmless.

For licensing information, contact:

Cornell Center for Technology Enterprise and Commercialization
Attention: Executive Director
395 Pine Tree Road, Suite 310
Ithaca, NY 14850

Fax: 607-254-5454
Phone: 607-254-5236
Email: cctec-contracts@cornell.edu
Cite: Docket D4184 (LRRK2) and D5203 (alpha-synuclein)