huNOG

Constitutive Knock Out

NOD Background

  • Model #
  • Genotype
  • Nomenclature
  • HSCFTL-NOG-F
    sp/sp;ko/ko
    NOD.Cg-Prkdcscid Il2rgtm1Sug/ JicTac
  • HSCCB-NOG-F
    sp/sp;ko/ko
    NOD.Cg-Prkdcscid Il2rgtm1Sug/ JicTac
  • NOG mice engrafted with human CD34+ hematopoietic stem cells (HSCs) stably develop multiple cell lineages by 12-16 weeks post-injection.
  • Human lymphocytes are present in peripheral blood, bone marrow, thymus and spleen.
  • Long term studies are possible in huNOG mice, with literature reports of stable engraftment and hematopoiesis for one year or more. However, not all human immune cell types are present, and some cell types may not be completely functional.

Taconic maintains an inventory of female huNOG mice engrafted as juveniles and FACS tested at 12+ weeks post-engraftment; all mice are ≥25% hCD45+ in peripheral blood. Custom options for huNOG generation and assessment of engraftment are available, such as HLA matching and age of engraftment.

Availability:

For a limited time, Taconic Biosciences is offering a trial program to enable you to validate the huNOG model in your research facility.

Color:

Albino

Species:

Mouse