B6 Albino

Targeted Replacement

B6 Albino Targeted Replacement Mouse Model

C57BL/6NTac Background

  • Model #
  • Genotype
  • Nomenclature
  • 11971-F
    ki/ki
    C57BL/6NTac-Tyrtm1Arte
  • 11971-M
    ki/ki
    C57BL/6NTac-Tyrtm1Arte
  • A new and improved B6 Albino strain based on the C57BL/6NTac substrain.
  • Contains a mutation in the Tyr gene to introduce albinism
  • The Taconic B6 Albino is an ideal host for maintaining substrain specificity of ES cells derived from the C57BL/6NTac substrain
  • May be used as a blastocyst host for B6 ES cells with an agouti mutation
  • Can also be used as a genetic background for models in which a B6 background is needed with an albino coat, for example in imaging applications
  • Available only from Taconic!

B6 Albino Germline

Genetic Background:

C57BL/6NTac Background

Origin:

The B6 Albino model was developed by Taconic. The Tyr mutation is a constitutive knock in of a point mutation in which a G nucleotide located at position 369 in exon 1 has been replaced with C nucleotide, resulting in an amino acid substitution at position 103 (Cys>Ser). The F3 site flanked selection marker was removed by via Flp recombinase. This mutation was made in the C57BL/6NTac substrain. The line was intracrossed to homozygosity.


Availability:

Production at Danish facilities ended on December 31, 2015. This model is produced in the U.S. and available to ship internationally.

Genetics:

Use the Taconic B6 Albino as a blastocyst donor for agouti JM8A3 ES cells.   Use of the Taconic B6 Albino as a blastocyst donor for JM8A3 ES cells permits detection of germline transmission by coat color in 100% of pups. G1 germline pups are heterozygous at one or two coat color loci.


Color:

Albino

Species:

Mouse

Initial Publication:

Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G. (2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One. 2014 Mar 5;9(3):e90570.   



Conditions of Use for Taconic B6 Albino (Taconic model #11971 )
The Taconic B6 Albino (Taconic model #11971) was developed by Taconic and is produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of the Sale and following terms of use:

  • Title to Taconic B6 Albino model, progeny and biological materials derived from them remains with Taconic.
  • The Taconic B6 Albino model may be used or bred and used for internal non-commercial research purposes only.
  • The Taconic B6 Albino model, progeny and biological materials derived from it will not be distributed to third parties, sold or resold or used for commercial purposes without express written permission from Taconic.

Note: Users who would like to use the B6 Albino as part of commercial fee-for-service transgenic core services should contact Taconic for terms.