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Humanized Mouse Models

WEBINAR: Taconic Biosciences' Dr. Leon Hall on key humanized immune system mouse models and their uses.

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  • Immune System Humanized Mice: Enabling a New Frontier in Drug Discovery

    The immune system is a complex orchestration of blood and tissue cells that protect us from pathogenic invaders like bacteria, and viruses.  Our knowledge of the immune system has grown exponentially over the past twenty five years, with a multitude of discoveries originating from studies in wild type... Read more

  • GEMs Risk Management

    When our computers crash, we immediately panic, wondering if our data will be lost forever. We recall how often our Information Technology department reminds us to back up our data and how often we ignore this suggestion. Now, how about rodent lines? Who reminds us to back up our unique genetically engineered... Read more

  • New Publications Suggest Gut Microbiota Play a Key Role in Disease Progression

    Two recent publications provide further evidence that the gut microbiota play a key role in disease progression, and additionally, the valuable role that germ free mice can play in helping to elucidate those key roles. In each study summarized below, mice with conventional gut flora and germ free mice... Read more

  • Taconic Brings Together the Scientific Community for Discussion of Humanized Mouse Models

    Taconic Biosciences recently organized and hosted a symposium on "The NOG platform: advanced models for immune system humanization and oncology research" in the Boston area. The half-day event gathered experts from the US and Japan to discuss the impact of the NOG mouse and related models in biomedical... Read more

  • Challenges and Prospects in Predicting the ADME and Toxicity Characteristics of Drugs in Humans

    One of the key challenges of drug development is to better predict drug responses in humans. This white paper offers insights on how such challenges are being overcome by a portfolio of pre-validated in vivo and in vitro tools. These tools offer solutions along various stages of the drug development... Read more

  • Application of CRISPR/Cas-based Technology

    CRISPR/Cas-based gene editing has recently emerged as a versatile technology for inducing precise genetic alterations in a number of different species, including mice and rats. Given the importance of genetically engineered mice in modeling human disease, the power of CRISPR has the potential to revolutionize... Read more

  • Are researchers making the most of germ-free models?

    "All of this indicates that the study of germ-free life has reached a certain maturity." - James A. Reyniers, 1959 In the years immediately following Reyniers optimistic statement on the maturity of germ-free technology, there was a burst of publications, which leveled off (with oscillations around a... Read more

  • Reducing Animal Use Through State-Of-The-Art Model Generation

    "Reduction remains of great importance, and of all modes of progress it is the one most obviously, immediately, and universally advantageous in terms of efficiency." -W.M.S. Russell and R.L. Burch1 The concept of the three Rs - replacement, reduction, and refinement--in research animal use were first... Read more