Transporter Panel

Humanized and Knockout Mouse Models For In Vivo Applications

Drug transporters mediate uptake and extrusion of many compounds across biological barriers and can have profound effects on absorption, distribution metabolism, excretion, and toxicity (ADMET) of potential therapeutics. There is an increasing requirement to understand the role of such transporters on the ADMET characteristics of compounds in drug development, as highlighted by the recent white paper from the International Transporter Consortium (Nat Rev Drug Discov. 2010 Mar; 9(3):215-36). We offer a unique portfolio of transporter humanized and knockout mouse models which can be used for different in vivo applications.
  • Use of pure inbred genetic background (either C57BL/6 or FVB). This will minimize variance between mice and increase reproducibility of results.
  • Corresponding mouse genes are deleted in the humanized models.
  • Pre-validation data available.

Transporter Panel

Knockouts Humanized
Bcrp BCRP**
Mdr1a
Mdr1a/b MDR1
Mdr1a/b-Bcrp
Mrp1
Mrp2 MRP2
Oatp1a/1b OATP1B1
OATP1B3
OATP1B1-1B3
Oct1/2