tADMET™ Portfolio

Translational Mouse Models, In Vitro Tools and Services

A unique and evolving portfolio of translational (humanized & knockout) mouse models, in vitro tools and services for an improved prediction of the Absorption, Distribution, Metabolism, Excretion, and Toxicity characteristics of new compounds in humans.
Humanized and knockout mice of ADMET related genes
Liver humanized mouse models
Carcinogenicity models Contract Services
  • Drug-drug interactions
  • Human metabolite testing
  • Assessment of bioavailability and clearance
  • PKPD modeling
  • Carcinogenicity testing
  • Infectious diseases
  • Drug Metabolism
  • Toxicity testing
  • Improved drug candidate selection
  • Higher clinical success rates
  • Reduced costs
  • Support drug approval by regulators
  • Support of scientific publications
  • Scheer N, Wolf CR. (2013) Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications. Xenobiotica. 44(2):96-108.

Genetically Engineered Mice

Xenoreceptor Panel

Cytochrome P450 Panel

Phase 2

Transporter Panel

Knockouts Humanized Knockouts Humanized Humanized Knockouts Humanized
Ahr AHR Cyp1a1/1a2* CYP1A1/1A2** UGT1A1*1** Bcrp BCRP**
Car CAR Cyp2c CYP2C9 Mdr1a
Pparα Cyp2d CYP2D6 Mdr1a/b MDR1**
Pxr PXR Cyp3a (7-gene) CYP3A4/3A7 Mdr1a/b-Bcrp
Pxr-Car PXR-CAR Cyp3a (8-gene) Liver CYP3A4 Mrp1
Pxr-Car-Ahr PXR-CAR-AHR* Gut CYP3A4 Mrp2 MRP2
Pxr-Car-Pparα** PXR-CAR-PPARα** Liver & Gut CYP3A4 Oatp1a/1b OATP1B1
Cyp2f2 CYP2A13-CYP2F1-CYP2B6 OATP1B3
Cyp2c-Cyp2d-Cyp3a** OATP1B1-1B3

Composite Models (Humanized)

Tissue Humanized Models

Carcinogenicity Models

Related Models

PXR/CAR/CYP3A4/3A7/CYP2D6** TSG-p53® (N5) Mouse HRN™ nude
**Coming soon