EZcohort™ Models

Lab tech working with cryopreservation materialsObtaining the right genetically engineered models (GEMs) in a simple, fast, and transparent way is essential to drive your research program forward, yet accessing cryopreserved lines can be cumbersome. To provide customers with valuable animal models without the burden of lengthy legal negotiations and undefined deliverables Taconic Biosciences has created the EZcohort™ models collection to ensure easy access to a select group of GEMs. EZcohort™ models are distributed under clear terms of use and include rights to use, breed, and crossbreed for three years.

Easy access means starting your project sooner

EZcohort™ models are distributed under simple label license terms that grant the purchaser rights to use, breed and crossbreed for three years. The full conditions of use are located on any EZcohort™ model page by clicking on the 'Licensing' accordion.

The Deliverable

You will receive a cohort of 4 mutants (at least heterozygous for all alleles) within 12-16 weeks of placing your order to jump-start your breeding colony.

Want to start with a different cohort size? Contact our breeding management experts to discuss options to grow your colony faster.

Receiving breeders is just the start. Every EZcohort™ order comes with accompanying support material. Upon purchase, you receive a colony maintenance instruction pack that includes:

  • PCR genotyping protocol and links to genotyping outsource options
  • Mating instructions and historical breeding performance data
  • SNP testing resources and advice to monitor genetic drift

  • What are EZcohort™ models?
    EZcohort™ models are a collection of Taconic's cryopreserved, or very small maintenance colony genetically engineered models.

  • Why is it called "EZcohort™"?
    Taconic has made it easy for researchers to access these models through the use of a simple label license and predefined cohort sizes. The label license conditions of use are visible on each EZcohort™ model page, under the licensing accordion. Other providers require you to go through the time-consuming process of negotiating an MTA before you can access the models.

  • Can I just place an order and receive the model?
    Yes. An order can be submitted along with a PO or credit card and the cryorecovery will begin automatically.

  • Are EZcohort™ models cryopreserved?
    In general, EZcohort™ models are cryopreserved and require cryo-recovery. However, in some cases, lines may have very small live colonies.

  • How long does it take to receive the model?
    EZcohort™ models program delivers a minimum of 4 mixed sex mice that are at least heterozygous for the mutant alleles. They will be delivered to you in 12-16 weeks.

  • Can I breed these mice at my facility?
    Yes. Our conditions of use allow you to breed or cross breed the mice for a period of 3 years. This is included in the purchase price.

  • What if my project goes beyond 3 years?
    Near the end of the 3 year term, Taconic will contact you to see if you are interested in extending the use period.

  • What if I want more than 4 mice?
    No problem. If you require more than 4 mice, we will immediately put you in contact with one of our Scientific Program Managers. They will work with you to develop a breeding program that will meet the goals of your study. Learn more about Taconic's Scientific Services.

  • Can I request cryopreserved sperm or embryos?
    Unfortunately, we cannot provide cryopreserved materials.

  • What health standard are EZcohort™ models delivered at?
    All mice are shipped with an MPF™ Health Standard. The Taconic MPF™ Health Standard is universally accepted at laboratory animal facilities throughout the world.

  • What if I want the models at a higher health standard?
    No problem. We will have you engage with one of our Scientific Program Managers to discuss the specific needs of your project.

  • I searched all your models and can't find the one I require for my studies. Can you help?
    Yes. Taconic is a fully licensed provider of model generation services and Scientific Program Managers can help you. Please contact us with questions and for more information.

  • How are EZcohort™ models different from the Knockout Repository, and GEM Collections?
    The GEM Collection and the Knockout Repository are collections of genetically engineered models with special licensing terms to ensure our customers are able to freely conduct their research. For instance, the GEM Collection requires an MTA, and is restricted to non-profit customers. The EZcohort™ models are available under a simple label license, which streamlines the model recovery process by removing the requirement for MTAs.

  • Will I need to pay for shipping costs?
    Standard shipping charges apply.

  • How is the 3 year license term tracked?
    Taconic's legal department will follow up annually with a simple request to confirm ongoing breeding and use. At the end of the third year, a continuation agreement and maintenance fee will be sent.

  • What if the cryo-recovery fails?
    While we take every precaution to ensure a project is completed on time, in rare instances cryo-recoveries fail. If this should happen with your project, you will be contacted immediately. We will work with you to discuss the implications of the first attempt, and recommend the next steps. In many cases, we immediately schedule a second attempt to recover and provide a revision to the timeline.