Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Combination Immunotherapy Research with Syngeneic Tumor Models

In combination immunotherapy research, the goal is to coach multiple aspects of the body's own immune system to recognize and destroy cancerous cells. This strategy holds the promise of treating advanced tumors and keeping them at bay, with better responses and fewer side effects compared to more traditional chemotherapies. This has involved a paradigm shift in how scientists approach cancer research. For decades, the field has been...

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Targeting APOE4 for Alzheimer's Disease Therapies

Past research efforts, focused on Alzheimer's disease (AD) pathology and the genetics of familial AD, led to the discovery of important AD-related proteins, including amyloid-beta (Aβ) and tau. However, efforts to develop AD therapies based on targeting Aβ and tau have largely failed. Years of disappointing trials have brought increasing demand for new AD targets and alternative treatment approaches. Using mice expressing apolipoprotein E4 (apoE4), a human...

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Using HLA Transgenic Mice to Investigate Novel T Cell Therapies

Recent clinical successes in immuno-oncology, coupled with developments in genetically engineered mouse models, are driving interest in utilizing new aspects of immune cell biology for drug discovery. One promising class of cell-based treatments is Chimeric Antigen Receptor T (CAR-T) cell therapies, which take advantage of fundamental mechanisms of immune cell biology to develop novel, tumor-killing T cell therapies. T cell receptors (TCRs) are the antigen recognition machinery...

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Gnotobiotic Mouse Technology: An Illustrated Guide (Book Review)

A recently published illustrated manual on gnotobiotic mouse technology could be a great help to developing common standards in the germ-free research community. Chriss J. Vowles, Natalie E. Anderson, and Kathryn A. Eaton of the University of Michigan have produced a thorough reference in Gnotobiotic Mouse Technology: An Illustrated Guide (CRC Press). The Guide features an overview of germ-free research history with sections on sterilization, testing, rederivation,...

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Mother's Diet Influences Alzheimer's Disease Outcomes

Increasingly obesity and its associated comorbidities (cardiovascular disease, type 2 diabetes mellitus, hypertension, etc.) are identified as risk factors for Alzheimer's disease (AD). Determining the link between diet and Alzheimer's disease has been challenging, in large part due to obesity's association with numerous systemic physiological changes. Recent studies suggest that poor maternal diet can influence epigenetic changes which predispose offspring to the development of metabolic syndromes. Since...

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Big Week for Immuno-Oncology Therapeutics

We've heard a lot about immune checkpoint inhibitor drugs in the news this week. Most notably, Merck & Co., Inc. (Merck) shared two major announcements involving their anti-PD-1 monoclonal antibody, Keytruda®. First, in a press release on October 21st, Merck announced the stoppage of a Phase III clinical trial for bladder cancer. Covering the announcement, BioSpace Online reported that "early results were so positive that the DMC...

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Webinar: Humanized Mice in HIV Drug Discovery

Human immunodeficiency virus (HIV) and acquired immune deficient syndrome (AIDS) caused by HIV continue to impact approximately 36.7 million people worldwide. In the United States alone it is estimated that 50,000 new HIV infections occur each year, and that nearly one in eight HIV carriers are unaware of their status. Thanks to improvements in combined antiretroviral therapy (cART), HIV is no longer a death sentence. But despite...

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Society for Neuroscience 2016 Abstracts - By the Numbers

In a little less than a month, 30,000 scientists will gather in San Diego for Society for Neuroscience 2016 Annual Meeting. Over 15,000 abstracts have been accepted for presentations in symposia, mini-symposia, and posters. There will be more than 100 satellite events being held in conjunction with the annual meeting with at least 600 exhibitors showcasing new tools and technologies. The volume of information and insight on...

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FAQ: Animal Models for Microbiome Research

The microbiome is emerging as an important factor in disease development, progression and prevention. Researchers are trying to harness the microbiome and its role in immune response for therapeutic purposes. Gnotobiotic and germ-free mice will play a pivotal role for researchers. To better serve the research community, it is critical for model vendors to test and report on more microbes of interest and make available a variety...

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Fourth Quarter Microbiome Conferences Roundup

Are you looking for a good scientific microbiome research symposium? Over the next three months, you have six exciting microbiome conferences from which to choose. Symposium Date Location World Congress on Targeting Microbiota 2016 10/17/16 to 10/19/16 Paris, France Gut Microbiome 2016 - An International Perspective 10/21/16 to 10/22/16 Manipal, India Advancing Microbiome Research Symposium: Microbiome & Disease 11/03/16 Potomac, MD International Human Microbiome Congress (IHMC) 11/9/16...

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