Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Comparison Guide: huNOG-EXL, NSG-SGM3 and MISTRG

Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but each one has different features which must be considered when choosing an experimental model. Each model expresses two or more human variants...

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Meeting report: International Workshop on Humanized Mice 5

More than 300 scientists in the humanized mouse field gathered in Zurich for three days of stimulating presentations and discussions at the International Workshop on Humanized Mice 5 (IWHM5). Click for full size PDF Several groups reported generation of new models via novel human cytokine expression methods onto existing super immune deficient host mice. By presenting a series of random pronuclear transgenics and targeted knock-ins, various researchers...

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Patient-derived xenografts - a critical tool for oncology research

Researchers developing new cancer drugs have used xenografts to model human tumors for decades. With the development of immortalized cell lines, starting with HeLa, and the discovery of immunocompromised mutant mice, these two tools could be combined for in vivo human tumor studies. However, the translational relevance of cell line xenografts has been questioned. While they are still used widely as screening tools to provide go/no decisions...

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Three reasons you shouldn't use heterozygous nude mice or rats as sentinels

If you are reading this you already know that the use of sentinel animals in research and production colonies is critical to facilitate health monitoring and maintain animal quality. A sentinel animal must have a strong but not excessive immune response to infectious agents, with the ability to seroconvert to viral agents. You are also probably aware that commonly used models include: the hearty outbred Swiss Webster...

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Mouse Gut Microbiota... That's funny

As often happens in science, such as Greatbath with the pacemaker and Fleming with penicillin, great discoveries sometimes find you. As Asimov said "The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' but 'That's funny...' Many scientists are making similar discoveries related to the role of the microbiome in research. Click for full size image As Jim Vitale observed...

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Advancing Microbiome Research Symposium

On September 29th, I had the pleasure of attending Advancing Microbiome Research Symposium: Microbiome & Mice in Cambridge, MA. The complimentary full-day program was hosted by Taconic Biosciences and featured speakers from University of Pennsylvania, Yale, Columbia, University of Minnesota, Massachusetts General Hospital and University of Virginia came and presented new and relevant information concerning the role of the microbiome in immune response and in contributing to...

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Aging and the Immune Response to Influenza Infection

In a recent presentation at Taconic Biosciences, Dr. Laura Haynes, Professor at the Center on Aging, Department of Immunology at the UCONN School of Medicine, discussed how aging affects immunological responses. Her lab utilizes an influenza virus infection mouse model. Aging has dramatic effects on many body systems; almost every aspect of immune response is changed with aging including adaptive immune cells (T & B), spleen and...

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Discover huNOG-EXL: Extending the Limits of Engrafted Human Immune System Models

Taconic Biosciences' Dr. Michael Seiler, Associate Director, Genetically Engineered Models Design and Precision Research Models, presented a webinar featuring some of the latest applications of Taconic's newest extended lineage NOG model, huNOG-EXL, designed for applications in allergy, inflammation and immuno-oncology research. Learn more about engrafted human immune models and their impact for allergy, inflammation and immuno-oncology research. The development of animal models capable of mimicking human immune...

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The NOG platform expands - new human cytokine transgenics

Dozens of papers have demonstrated the utility of the CIEA NOG mouse® for human immune system engraftment. Several systems are commonly used for human immune engraftment, each with their own advantages and disadvantages. Human hematopoietic stem cells can be engrafted to generate huNOG mice, which support long-term differentiation of multiple cell lineages. A simpler system is the huPBMC-NOG, in which mature human peripheral blood mononuclear cells are...

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Book Review: Humanized Mice for HIV Research

HIV researchers have been challenged in finding a suitable small animal model, as rodents such as mice and rats cannot be infected by HIV. Existing animal models such as chimpanzees are not ideal as they are expensive, more challenging to work with and have a higher ethical burden for use. Furthermore, while some non-human primates (NHPs) can be infected with HIV, they do not develop similar disease...

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