Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Discover huNOG-EXL: Extending the Limits of Engrafted Human Immune System Models

Taconic Biosciences' Dr. Michael Seiler, Associate Director, Genetically Engineered Models Design and Precision Research Models, presented a webinar featuring some of the latest applications of Taconic's newest extended lineage NOG model, huNOG-EXL, designed for applications in allergy, inflammation and immuno-oncology research. Learn more about engrafted human immune models and their impact for allergy, inflammation and immuno-oncology research. The development of animal models capable of mimicking human immune...

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The NOG platform expands - new human cytokine transgenics

Dozens of papers have demonstrated the utility of the CIEA NOG mouse® for human immune system engraftment. Several systems are commonly used for human immune engraftment, each with their own advantages and disadvantages. Human hematopoietic stem cells can be engrafted to generate huNOG mice, which support long-term differentiation of multiple cell lineages. A simpler system is the huPBMC-NOG, in which mature human peripheral blood mononuclear cells are...

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Book Review: Humanized Mice for HIV Research

HIV researchers have been challenged in finding a suitable small animal model, as rodents such as mice and rats cannot be infected by HIV. Existing animal models such as chimpanzees are not ideal as they are expensive, more challenging to work with and have a higher ethical burden for use. Furthermore, while some non-human primates (NHPs) can be infected with HIV, they do not develop similar disease...

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What do President Jimmy Carter and Taconic's huNOG mice have in common?

In a press conference on August 20, 2015, former US President Jimmy Carter announced that he was diagnosed with stage four, metastatic melanoma. During the press conference President Carter revealed that the cancer had spread to his liver and brain, and while inoperable, he was undergoing aggressive last-line treatment. Read the August 12th and August 20th press releases. He remained steadfast and optimistic, yet the meaning of...

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Additional Mouse Models Added To The Cancer Research Technology Repository

Taconic Biosciences has recently added an additional 6 mouse lines to the Cancer Research Technology (CRT) Repository as part of the Emerging Models collection. The CRT repository provides academic and non-profit researchers with worldwide access to multiple genetically engineered mouse models that may be particularly useful for cancer research. CRT is a specialist development and commercialization company, which aims to advance new discoveries in cancer research for...

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What do CRISPR, the number 62 and pigs have in common?

The American Transplant Foundation reports that there are currently 123,000 people in the United States on a waiting list for an organ transplant. On average, 21 people die every day from the lack of available organs for transplant. Extending that number out to the worldwide population would put the number of people, worldwide, who need organ transplants at 2.7 million people and just under 500 people die...

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scid mutants or Rag2 knockouts - Which immunodeficient model is best for your study?

Mice with compromised immune systems are invaluable research tools. Starting with the discovery of athymic nude mice in the 1960's, the portfolio of immunodeficient rodents has grown significantly. Although these models are used quite widely, not all researchers understand their intrinsic characteristics and how those characteristics impact experimental outcomes. Learn more about two key immunodeficient models, scid mutants and Rag2 knockouts, and how to choose the most...

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Tbk1 Gene Function - New Model Utility

Image shows iPS derived motor neurons from an ALS patient. Tuj 1 ab shown in red and Hb9 ab in green.1 Knockout (KO) mouse models are important tools for defining mammalian gene function though it is often the case that a single gene will play different roles in different physiological contexts. A relevant example is the novel function recently attributed to the mouse TANK binding kinase 1...

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Academic Research - Pool of available GEMs increases by 75 models

Taconic Biosciences has recently added an additional 75 mouse models to the GEM Collection Repository. The GEM Collection's nearly 300 lines provide academic and nonprofit researchers worldwide with unparalleled access to a wide range of genetically engineered mouse models. These mouse models are relevant to several disease areas, such as cardiovascular, diabetes/ endocrinology, neuroscience, oncology, respiratory, and immunology. The GEM Collection repository offers nonprofit researchers immediate access...

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Insights from the huNOG production Lab - Product integrity

Two questions often posed about the production of human immune system engrafted mouse models are "how reproducible and therefore how reliable is the engraftment process?" These are valid questions, and they must account for many variables. For Taconic's engrafted models program, outstanding proficiency and strict adherence to production practices have eliminated some of the technical barriers to reliable human immune system engrafted mouse (i.e. huNOG) production. However,...

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