Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Webinar: Humanized Mice in HIV Drug Discovery

Human immunodeficiency virus (HIV) and acquired immune deficient syndrome (AIDS) caused by HIV continue to impact approximately 36.7 million people worldwide. In the United States alone it is estimated that 50,000 new HIV infections occur each year, and that nearly one in eight HIV carriers are unaware of their status. Thanks to improvements in combined antiretroviral therapy (cART), HIV is no longer a death sentence. But despite...

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Society for Neuroscience 2016 Abstracts - By the Numbers

In a little less than a month, 30,000 scientists will gather in San Diego for Society for Neuroscience 2016 Annual Meeting. Over 15,000 abstracts have been accepted for presentations in symposia, mini-symposia, and posters. There will be more than 100 satellite events being held in conjunction with the annual meeting with at least 600 exhibitors showcasing new tools and technologies. The volume of information and insight on...

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FAQ: Animal Models for Microbiome Research

The microbiome is emerging as an important factor in disease development, progression and prevention. Researchers are trying to harness the microbiome and its role in immune response for therapeutic purposes. Gnotobiotic and germ-free mice will play a pivotal role for researchers. To better serve the research community, it is critical for model vendors to test and report on more microbes of interest and make available a variety...

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Fourth Quarter Microbiome Conferences Roundup

Are you looking for a good scientific microbiome research symposium? Over the next three months, you have six exciting microbiome conferences from which to choose. Symposium Date Location World Congress on Targeting Microbiota 2016 10/17/16 to 10/19/16 Paris, France Gut Microbiome 2016 - An International Perspective 10/21/16 to 10/22/16 Manipal, India Advancing Microbiome Research Symposium: Microbiome & Disease 11/03/16 Potomac, MD International Human Microbiome Congress (IHMC) 11/9/16...

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When Are Nude Rats Better?

Researchers have a wide range of immunodeficient mouse models from which to choose a suitable experimental host, including nudes, scids, Rag2 knockouts, and super immunodeficient models such as the CIEA NOG mouse®. Each model offers different strengths and weaknesses, but one commonality is that they are all commonly used to host xenografts. With such a wide range of mouse models, why would you need an immunodeficient rat?...

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Variations within Outbred Strains: Know Your Strains and Stocks

The Sprague Dawley® (SD) rat is one of the most popular outbred stocks, with application across many therapeutic areas as well as ADMET studies. The SD is an outbred stock, meaning that there is genetic variation within the stock, and each individual varies in genetic makeup. Genetic variation is maintained through well-defined rotational mating schemes, which are designed to maintain heterozygosity within the population over time. The...

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Improving Lives by Modeling Rare Genetic Disorders

Relief for patients with rare genetic disorders are often out of reach, due to the expense of developing genetically engineered animal models. That's why the Rare Genomics Institute, Taconic Biosciences, and Jonah's Just Begun came together to develop and characterize a model of Sanfilippo Syndrome. Sanfilippo Syndrome is a progressive, devastating rare genetic disorder affecting approximately 1 in 70,000 children. There are four subtypes of the disease,...

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What's in a Name? Origins of the CIEA NOG mouse®

The CIEA NOG mouse® is often referred to as an ideal mouse for engraftment of foreign (especially human) cells. The high rates of engraftment make NOG mice a preferred choice for patient-derived xenografts and humanized immune system mice studies. What special properties make the NOG mouse such a great acceptor of foreign cells and tissues? To answer this question, one need only look at the mouse line's...

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Modeling Proprioception

NPR recently published "How A 'Sixth Sense' Helps Simone Biles Fly, And The Rest Of Us Walk", that explored proprioception - the sense of the relative position of neighboring parts of the body - with a story on children with a rare mutation in a gene called PIEZO2. When Damiana was younger, her condition baffled doctors, says her mother, Diana Sawyer. "She was very late at doing...

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Biotechnology Patents and Genetically Modified Organisms

How do biotechnology patents affect the generation, use and distribution of genetically modified organisms, such as knockout mice or transgenic animal models? What is a licensing agreement and what are the implications of licensing (or not licensing) methods and technologies used in biomedical research? Can you use the new model you recently obtained from a collaborator for your research program? In a nutshell, patents protect intellectual property...

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