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Swiss nude

SPONTANEOUS MUTANT T-CELL DEFICIENT MICE
 

Swiss Background

Model Number Zygosity Nomenclature
NSWNU-F Homozygous
NTac:NIHS-Foxn1nu
NSWNU-M Homozygous
NTac:NIHS-Foxn1nu
NSWNU-F Heterozygous
NTac:NIHS-Foxn1nu
NSWNU-M Heterozygous
NTac:NIHS-Foxn1nu
  • Description
  • Health Report

Model Description

  • An outbred athymic model originating from the NIH Genetic Repository
  • This outbred stock is frequently used for implants of human tumors for purposes of chemotherapeutic screening
  • Maintained in flexible-film isolators under gnotobiotic conditions
  • The autosomal recessive nude gene in homozygous (nu/nu) mice causes the lack of fur and an abnormal thymus. The deficiency in T-cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues
  • Heterozygous (nu/+) animals carry the recessive nude gene on one chromosome only and therefore have a normal thymus triggered immune system

Origin: Taconic received the Swiss nude Spontaneous mutant model from the NIH Animal Genetic Resource in 1976. The mice were derived by hysterectomy in 1989 and are maintained in gnotobiotic isolators on strict defined flora.

Color: Albino

Coat Color Loci:  
Tyrc


Animal Diet: NIH #31M Rodent Diet