An outbred athymic model originating from the NIH Genetic Repository
This outbred stock is frequently used for implants of human tumors for purposes of chemotherapeutic screening
Maintained in flexible-film isolators under gnotobiotic conditions
The autosomal recessive nude gene in homozygous (nu/nu) mice causes the lack of fur and an abnormal thymus. The deficiency in T-cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues
Heterozygous (nu/+) animals carry the recessive nude gene on one chromosome only and therefore have a normal thymus triggered immune system
Taconic received the Swiss nude Spontaneous mutant model from the NIH Animal Genetic Resource in 1976. The mice were derived by hysterectomy in 1989 and are maintained in gnotobiotic isolators on strict defined flora.
Coat Color Loci:
Animal Diet: NIH #31M Rodent Diet