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CIEA NOG mouse®

Emerging Model Spontaneous Mutant/Targeted Mutation Mice
 

NOD Background

Model Number Zygosity Nomenclature
NOG-F Homozygous/Homozygous NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac
NOG-M Homozygous/Hemizygous NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac
  • Description
  • Health Report

Model Description

  • Immunodeficient model lacking mature T, B, and NK cells
  • Displays reduced complement activity
  • Has dysfunctional macrophages and dendritic cells
  • Displays no leakiness of T and B cells with increasing age
  • Very low incidence of lymphoma (unlike NOD scid model)
  • Does not develop diabetes
  • Excellent model for a variety of xenograft and human cell engraftment studies
  • Applications in research involving cancer, infectious disease, immunology, regenerative medicine, and humanization
  • The Il2rg gene is sex-linked

Origin: The CIEA NOG mouse® was developed by Mamoru Ito of the Central Institute for Experimental Animals (CIEA) in Japan. The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. This mutation was backcrossed onto the NOD/ShiJic strain at CIEA for at least eight generations. The Il2rg targeted mutation was developed by Dr. Kazuo Sugamura of Tohoku University by targeting the gene in ES cells derived from a 129 strain. Portions of exons 7 and 8 were replaced with a neo cassette. Targeted ES cells were injected into C57BL/6 blastocysts. Resultant chimeras were backcrossed onto the C57BL/6JJic background for at least eight generations. The CIEA NOG mouse® was developed by backcrossing the C57BL/6JJic-Il2rg line to the NOD/ShiJic-Prkdc scid line for a total of eight generations. Taconic received stock in 2006, and the line was derived through embryo transfer. The CIEA NOG mouse® colony was refreshed in 2011 via rederivation of new stock using donors sourced from the CIEA NOG mouse® foundation colony at CIEA. The mice are maintained by breeding females homozygous for both the Prkdc scid and Il2rg mutant alleles with males that are homozygous for the Prkdc scid allele and hemizygous for the Il2rg mutant allele.

Availability: Available now for immediate delivery!

Color: Albino

Initial Publication: 
Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, Heike T, Nakahata T. (2002) NOD/SCID/γ mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-3182.


Animal Diet: NIH #31M Rodent Diet

Licensing Requirements:

Non-profit users (excluding users at non-profit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for non-profit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions

Does your research require the use of neonates? Please sign up for more information on neonate access options.

For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.

Does your research require the use of neonates? Please sign up for more information on neonate access options.



The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
Japanese Patent No. 3,753,321
US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
EP Patent No. 1,338,198
Japanese Trademark Reg. No. 4,823,423
US Trademark Reg. No. 3,118,040
EU Trademark Reg. No. 3,736,758