Extensively used as an experimental animal in many fields of general biology as well as in pharmacology and toxicology
Commonly used as a control for selection experiments
Develops a wide variety of spontaneous tumors and an increasing incidence of renal disease with age
Origin: The NMRI outbred model was developed by Lynch et al. Poiley of the National Institutes of Health received stock from Lynch in 1937. The mice were inbred as NIH/P1. The Naval Medical Research Institute (NMRI) received stock from Lynch. Zentralinstitut für Versuchstierzucht in Hannover Germany (Han) received stock from NMRI. The mice were random bred. M&B A/S (now Taconic Europe) received stock from Han in 1961 and again in 1985. The mice are maintained as an outbred stock.
Genetics: Immunology: H2q
Coat Colour Loci: A/a, Tyrc