Extensively used as an experimental animal in many fields of general biology as well as in pharmacology and toxicology
Commonly used as a control for selection experiments
Develops a wide variety of spontaneous tumors and an increasing incidence of renal disease with age
The NMRI outbred model was developed by Lynch et al. Poiley of the National Institutes of Health received stock from Lynch in 1937. The mice were inbred as NIH/P1. The Naval Medical Research Institute (NMRI) received stock from Lynch. Zentralinstitut für Versuchstierzucht in Hannover Germany (Han) received stock from NMRI. The mice were random bred. M&B A/S (now Taconic Europe) received stock from Han in 1961 and again in 1985. The mice are maintained as an outbred stock.
Coat Color Loci: