Carries the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT) and expresses no TAU protein
Aggregates of filaments of TAU result in Neurofibrillary tangles (NFT) which are associated with Alzheimers disease, Pick disease and other neurological syndromes
Develops behavioral and motor disturbances related to development of NFT
Model 2508-M is homozygous for the transgene and develops a phenotype that mimics human tauopathies in a more rapid timeframe than the hemizygous model
Useful for studying Alzheimer's disease, Pick's disease and other neurological syndromes associated with NFT
The Tau mouse was developed in the laboratory of Mike Hutton at the Mayo Clinic. The model was created by microinjecting transgenic constructs containing the P301L mutation of the microtubule associated tau gene and mouse prion promoter into B6D2F1 x SW zygotes. The resultant mice from Founder Line JNPL3 were mated to B6D2F1. Taconic received stock in December 2000. The mice were derived by embryo transfer and mated to SW and B6D2F1 hybrids and embryo transfer derived. Offspring from both backgrounds were combined and are mated to B6D2F1 mice to produce hemizygous and wild type mice (1638). Hemizygous Tau mice were intercrossed to generate homozygous Tau mice. The homozygous colony is maintained by incrossing homozygotes.
Wildtype for Nnt mutation; carries Pde6brd1 mutation
Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein
. Nat Genet, 25(4):402-406
Conditions of Use for Taconic Transgenic Models™
Title to these Models and biological materials derived from them remains with Taconic Farms, Inc.
The Models will be used for research purposes only.
The Models will not be bred except to obtain embryos or fetuses required for research purposes
The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
Taconic Transgenic Models are produced in Isolated Barrier Unit (IBU™) facilities under MPF™ conditions, and shipped in Taconic Transit Cages (TTC™).