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APPSWE-Tau

MICROINJECTED
 

C57BL/6, DBA/2, SJL, SW Mixed Background

Model Number Zygosity Nomenclature
2469-F Hemizygous/Hemizygous STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-M Hemizygous/Hemizygous STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-F Wild Type/Hemizygous STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-M Wild Type/Hemizygous STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-RD1-F Hemizygous/Hemizygous/rd1 Heterozygous or Wild Type STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-RD1-M Wild Type/Hemizygous/rd1 Heterozygous or Wild Type STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-RD1-F Wild Type/Hemizygous/rd1 Heterozygous or Wild Type STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
2469-RD1-M Wild Type/Hemizygous/rd1 Heterozygous or Wild Type STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc
  • Description
  • Health Report
  • Phenotyping

Model Description

  • Carries the transgene coding for the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) protein in addition to the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT)
  • Amyloid plaque distribution, number, morphology and density is similar between APPSWE-Tau mice and APPSWE mice
  • Motor disturbances and morphology of neurofibrillary tangles (NFT) is comparable between the APPSWE-Tau and Tau mice, although older female APPSWE-Tau mice have a marked increase in limbic areas compared to Tau females
  • Useful for the study of Alzheimer's Disease that address both the formation of β-amyloid plaques and NFT and to study drugs for treatment or prevention of Alzheimer's disease
  • The 2469-TT mice are hemizygous for the APPSWE mutation and hemizygous for the Tau mutation.
  • The 2469-WT mice are wild type for the APP mutation and hemizygous for the Tau mutation and serve as one control for the 2469-TT model.
  • Model 3273-WW contains the same strain and stock genetic contribution as 2469, and serves as the double wild type control.
  • Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee.

Origin: The APPSWE-Tau double microinjected model was developed by mating homozygous female Tau mice with hemizygous male APP mice (002508-M female x 001349-T male). The resultant offspring are either hemizygous for both transgenes (002469-TT) or wild type for the APPSWE transgene and hemizygous for the Tau transgene (002469-WT). The APPSWE-Tau control model (003273-WW) was developed at Taconic to provide an appropriate genetic control for the APPSWE-Tau double microinjected model. The wild type APP-Tau control model is maintained by mating wild type Tau female mice (001638-W) to wild type APPSWE male mice (001349-W).

Color: Various

Genetics: 
Wild type for Nnt mutation; carries Pde6brd1 mutation


Initial Publication: 
Lewis J, Dickson DW, Lin W-L, Chisholm L, Corral A, Jones G, Yen S-H, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. (2001) Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and App, Science, 293(5534):1487 – 1491.


Animal Diet: NIH #31M Rodent Diet

Licensing Requirements:
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Farms, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.

Taconic Transgenic Models are produced in Isolated Barrier Unit (IBU™) facilities under MPF™ conditions, and shipped in Taconic Transit Cages (TTC™).