Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T. (2007) Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest. 117(11):3306-15.
Luo J, Ho P, Steinman L, Wyss-Coray T. (2008) Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease. J Neuroinflammation. 5:6.
Cordeau P Jr, Lalancette-Hébert M, Weng YC, Kriz J. (2008) Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injury. Stroke. 39(3):935-42.
Keller AF, Gravel M, Kriz J.(2009) Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells. Glia. 57(10):1130-42.
Tamgüney G, Francis KP, Giles K, Lemus A, DeArmond SJ, Prusiner SB. (2009) Measuring prions by bioluminescence imaging. Proc Natl Acad Sci USA. 106(35):15002-6.
Lee J, Borboa AK, Baird A, Eliceiri BP. (2011) Non-invasive quantification of brain tumor-induced astrogliosis. BMC Neurosci. 12:9.
Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. (2011) Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proc Natl Acad Sci USA. 108(6):2528-33.
Kainic acid treatment study:
Figure 1: The Gfap-luc transgene was induced following kainic acid treatment. Age-matched adult mice were treated for four days. Treatment with kainic acid triggered higher luciferase expression in brain, with increased expression and neuronal damage to the hippocampus (data not shown).
Meningitis infection study: The Gfap-luc transgene was induced to express luciferase in the brain (Figure 2) and the lumbar spine (Figure 3) of mice infected with Streptococcus pneumonia.